منابع مشابه
Role of CuZn superoxide dismutase on carotid body function in heart failure rabbits.
AIMS Peripheral chemoreflex sensitivity is potentiated in both clinical and experimental chronic heart failure (CHF). NADPH oxidase-derived superoxide mediates angiotensin II (Ang II)-enhanced carotid body (CB) chemoreceptor sensitivity in CHF rabbits, and tempol, the superoxide dismutase (SOD) mimetic, inhibits this Ang II- and CHF-enhanced superoxide anion effect. Here we investigated the rol...
متن کاملGene transfer of neuronal nitric oxide synthase to carotid body reverses enhanced chemoreceptor function in heart failure rabbits.
Our previous studies showed that decreased nitric oxide (NO) production enhanced carotid body (CB) chemoreceptor activity in chronic heart failure (CHF) rabbits. In the present study, we investigated the effects of neuronal NO synthase (nNOS) gene transfer on CB chemoreceptor activity in CHF rabbits. The nNOS protein expression and NO production were suppressed in CBs (P<0.05) of CHF rabbits, b...
متن کاملCentral role of carotid body chemoreceptors in disordered breathing and cardiorenal dysfunction in chronic heart failure
Oscillatory breathing (OB) patterns are observed in pre-term infants, patients with cardio-renal impairment, and in otherwise healthy humans exposed to high altitude. Enhanced carotid body (CB) chemoreflex sensitivity is common to all of these populations and is thought to contribute to these abnormal patterns by destabilizing the respiratory control system. OB patterns in chronic heart failure...
متن کاملCarotid body and sympathetic activation in heart failure: a story of sensors and sensitivity.
The carotid body (CB) is a peripheral chemoreceptor organ that contains clusters of electrically excitable secretory cells, the glomus cells, which express several types of membrane ion channels that influence its excitability. These cells act as sensors or chemotransducers, detecting different chemical stimuli and triggering an action potential in the afferent fibres that lie in synaptic appos...
متن کاملEnhanced activity of carotid body chemoreceptors in rabbits with heart failure: role of nitric oxide.
An enhanced peripheral chemoreflex has been documented in patients with chronic heart failure (CHF). This study aimed to examine the characteristics of carotid body (CB) chemoreceptors in response to isocapnic hypoxia in a rabbit model of pacing-induced CHF and to evaluate the possible role that nitric oxide (NO) plays in the altered characteristics. The chemosensitive characteristics of the CB...
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ژورنال
عنوان ژورنال: Respiratory Physiology & Neurobiology
سال: 2007
ISSN: 1569-9048
DOI: 10.1016/j.resp.2007.02.011